Linalool: the terpene in cannabis from lavender flowers

Linalool is the terpene characteristic of lavender odor, an aromatic compound found in many aromatic plants and of course in cannabis. In this post, we’ll look at what linalool is and how it can affect your cannabis experience.

What is linalool and what are the effects of this terpene in cannabis?

Introduction to linalool terpene

To learn about the properties of linalool, we propose a journey. A mental one, to a charming village in the province of Castilla La Mancha. Brihuega, for example. There, we invite you to stroll through this countryside of violet lavender fields, whose perfume permeates everything in mid-July.

When the sun goes down and the heat takes a break, sit down on that lavender-covered plain , and open some CBD Ohana (Hawaiian Rutz) flowers. . Do you smell that fragrance, that soothing aroma? If so, you are ready to understand the properties of the floral terpene par excellence: linalool.

What is linalool?

Linalool is a terpene, a volatile natural compound responsible for imparting odor to different plants, herbs, fruits and vegetables of the vegetable kingdom. Even though the name linalool may mean little to us, it is a scent that we unknowingly live with on a daily basis.

Linalool has a sweet floral aroma, with refreshing citrus notes in the background.

This aromatic compound is present in a multitude of cosmetic and hygiene products, and it is the characteristic scent of lavender that makes us choose a soap when we lift the cap and it releases such a clean, floral fragrance.

In fact, linalool is one of the most used terpenes in essential oil formulations for aromatherapy, and also one of the most used perfumes in creams.

Chemistry

It is an acyclic monoterpene composed of two isoprenes with two chains of five hydrocarbons each. Within the terpene family, it is one of the lightest terpenes, such as myrcene. myrcene or limonene . This means that it is very volatile, able to travel to our sense of smell quickly, and is therefore one of the first aromas we pick up when smelling cannabis.

What is the aroma of linalool?

Linalool has a sweet floral aroma. The easiest way to identify it is to think of the smell of lavender, which is one of the plants that produces the highest levels of linalool. Although the predominant fragrance of this monoterpene is floral, it also gives off refreshing citrus notes in the background.

That blend of flowers, mint and pepper makes it a calming scent that invokes relaxation. Let’s think of a lavender-scented shower gel and the rich sensation it leaves during bathing, and know that it is not the soap itself, but the terpene linalool that is the protagonist of such tranquility.

We have all been exposed to linalool numerous times, not only through the plants that produce it, but also through soaps, colognes or creams that formulate it within their ingredients. You already knew the terpene in this post, you just hadn’t named it yet.

Where is linalool found?

Linalool is present in more than 200 plant species, especially in the essential oil of herbs and spices, including the cannabis plant. cannabis plant which produces it in its trichomes trichomes . The emblematic plant of the linalool aroma is undoubtedly lavender, whose essential oil is composed of 30% linalool.

This monoterpene is also found in the essential oil of basil and thyme (linalool chemotype), in cardamom, sage, lemon balm and of course in marijuana flowers, among others.

CBD flowers rich in linalool

You can find linalool in the marijuana buds in the following Cannactiva strains:

Linalool rarely appears among the three terpenes with the highest levels in the results of the gas chromatography analysis, which are the ones that mark the odor of the variety. Even though it is a highly coveted terpene, what happens to the most expensive perfumes is that it is offered in small doses.

These sacred rations of the floral and calming terpene par excellence are found in the Zkittlez, the Do-Si-Dos, the Amnesia Haze. Those who have smelled the nuances of linalool in some genetics will return to it again and again in search of those olfactory notes so recognizable and so difficult to forget.

Which marijuana strains are rich in linalool?

If we type cannabis strains with linalool as the predominant terpene in any cannabis dispensary search engine we will find it difficult to find a genetic. Because, even though linalool is indeed present in cannabis, and although it has a large following, it is not usually a predominant terpene.

To preserve this unmistakable aroma, let us remember that linalool evaporates at 198 degrees Celsius.

How to identify the aroma of linalool in cannabis?

In cannabis plants, the aroma of linalool translates into a sweet floral undertone. Although it is a terpene present in some cannabis genetics, it is not the most common and is hardly one of the predominant terpenes of any strain.

Linalool is rarely the dominant terpene: it is rather the one responsible for providing organoleptic richness to the plant, the one that offers those differentiating nuances to the overall aroma of a given variety. If when you smell a CBD flower you perceive sweet, citric and refreshing floral notes , that bud has levels of linalool.

Effects of linalool in cannabis

Linalool is attributed with sedative and calming properties. It has also demonstrated potential anxiolytic and antidepressant benefits.

Linalool has a calming effect.

While it is true that some of these properties are enhanced by the entourage effect, some of these properties are entourage effect (also known as entourage effect). That is why the linalool in cannabis when used not in isolation, but in conjunction with other elements of the plant, offers greater benefits to the body, by acting in synergy with the effects of the other active compounds of the plant.

How does linalool interact with cannabinoids?

Due to the entourage effect, linalool (like other terpenes) can enhance the properties of some cannabinoids. On the one hand, and according to the conclusions of different studies compiled by Ethan B Russo in Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.the combination of linalool and limonene could Contribute to the clinical efficacy of CBD extracts, enhancing their anti-anxiety properties. by using them together (1).

The same would be true for the properties of cannabinoids to combat insomnia. Russo also estimated that the terpenes linalool , caryophyllene and myrcene, because of their sedative and anxiolytic properties, would enhance the properties of cannabinoids for better sleep. cannabinoids for better sleep (1).

It has also been observed that, even though linalool is effective in producing calming effects on its own, this sedative effect was amplified when combined with other terpenes such as citronellol and α-terpineol (3).

Benefits and properties of linalool

Plants rich in linalool such as lavender or lemon balm have traditionally been used in folk medicine for anxiety and depression. This terpene may have effects on the central nervous system, as demonstrated in animal studies but also in humans, offering anticonvulsant and sedative effects (4, 5, 6). In combination with β-pinene, it demonstrated antidepressant activity (7, 8).

Linalool is known to have sedative and calming properties. It can help reduce anxiety, stress and promote both mental and physical relaxation.

It has been observed that linalool could modulate GABAergic neurotransmission. GABA (gamma-aminobutyric acid) is a key inhibitory neurotransmitter in the nervous system, known to reduce neuronal excitability and promote relaxation. Linalool appears to interact with GABAA receptors and increase GABA activity, resulting in increased inhibitory tone in the nervous system. In other words: linalool would facilitate the action of the neurotransmitter GABA in the brain, leading to anxiolytic, sedative and relaxing effects (9).

I hope you enjoyed this tour through the aromatic nuances of cannabis. The next time you savor one of your favorite varieties, I invite you to sharpen your senses to discover those floral notes so characteristic of linalool. This terpene has unique sensations to offer you!

Referencias
  1. Russo E. B. (2011). Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British journal of pharmacology, 163(7), 1344-1364. https://doi.org/10.1111/j.1476-5381.2011.01238.x
  2. Raz N, Eyal AM, Zeitouni DB, Hen-Shoval D, Davidson EM, Danieli A, Tauber M, Ben-Chaim Y. Selected cannabis terpenes synergize with THC to produce increased CB1 receptor activation. Biochem Pharmacol. 2023 Jun;212:115548. doi: 10.1016/j.bcp.2023.115548. Epub 2023 Apr 19. PMID: 37084981.
  3. Russo E, Grotenhermen F. Handbook for cannabis therapeutics. From Bench to Bedside. The Haworth Press, Inc 2006.
  4. E. Elisabetsky, L.F. Brum, D.O. Souza, Anticonvulsant properties of linalool in glutamate-related seizure models, Phytomedicine 6 (1999) 107-113.
  5. E. Elisabetsky, J. Marschner, D.O. Souza, Effects of linalool on glutamatergic system in the rat cerebral cortex, Neurochem. Res. 20 (1995) 461-465.
  6. Y. Sugawara, A. Shigetho, M. Yoneda, T. Tuchiya, T. Matumura, M. Hirano, Relationship between mood change, odour and its physiological effects in humans while inhaling the fragrances of essential oils as well as linalool and its enantiomers, Molecules 18 (2013) 3312-3338.
  7. Guzman-Gutierrez SL, Bonilla-Jaime H, Gomez-Cansino R, Reyes-Chilpa R. Linalool and β-pinene exert their antidepressant-like activity through the monoaminergic pathway. Life Sci. 2015 May 1;128:24-9. doi: 10.1016/j.lfs.2015.02.021. Epub 2015 Mar 11. PMID: 25771248.
  8. Silvia Laura Guzmán-Gutiérrez , Herlinda Bonilla-Jaime, Rocío Gómez-Cansino , Ricardo Reyes-Chilpa. 2015 May 1. Linalool and β-pinene exert their antidepressant-like activity through the monoaminergic pathway.
  9. Koulivand PH, Khaleghi Ghadiri M, Gorji A. Lavender and the nervous system. Evid Based Complement Alternat Med. 2013;2013:681304. doi: 10.1155/2013/681304. Epub 2013 Mar 14. PMID: 23573142; PMCID: PMC3612440.
  10. US Department of Agriculture. Dr. Duke’s Phytochemical and Ethnobotanical Databases. https://phytochem.nal.usda.gov/

Jásminka Romanos
Periodista especializada en comunicación para el sector del cannabis

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