Does CBD get high? Myths about CBD - Cannactiva

Demystifying CBD: Does it really get high?

In recent years, cannabidiol or CBD has become a popular compound. And like any other compound that gains fame very quickly, it encourages the appearance of qualities or properties that could be erroneous. For example, there is some confusion about its effects, especially in relation to whether CBD produces a high, a high or a feeling of being “high”, similar to what happens with marijuana use.

Everything you need to know about whether CBD gets you high is summarized in this blog post from Cannactiva, the best CBD shop online. CBD Shop Online.

Does CBD get high?

CBD or cannabidiol is a chemical compound found in the cannabis plant. It is classified among the many types of cannabinoids present in this plant.

Along with tetrahydrocannabinol (THC), CBD is one of the cannabinoids found in the highest concentrations in cannabis, and has been widely studied and used for both recreational and therapeutic purposes.

Currently, CBD is the most widely used cannabinoid for medical purposes. Cannabidiol has a number of properties for use as an adjuvant treatment for various conditions such as chronic pain, anxiety and sleep disorders (1-7).

CBD vs. THC: key differences

For those not yet familiar with the subject, THC is the chemical compound responsible for the intoxicating effects associated with marijuana use, such as the feeling of being high, euphoria, and altered perception.

But, although they come from the same Cannabis sativa plant, there are differences between CBD and THC. differences between CBD and THC in terms of their effects on the organism. The biggest difference between CBD and THC is that they do not produce the same psychoactive effect, and that is because they act differently in the brain.

CBD does not place

No, CBD does not produce a psychoactive effect comparable to that of THC in marijuana. The psychoactive effect refers to the feeling of high, high, high or euphoria that is usually the effect for which marijuana is used recreationally.

Why does marijuana get high?

When marijuana is smoked or ingested, THC binds to and activates cannabinoid CB1 receptors, which are found in abundance in the brain.which causes a number of effects on the central nervous system, including the feeling of euphoria and alteration of perceptionwhich is what is known as high, high or high.

THC stimulates the release of dopamine in the brain’s reward system (in the nucleus accumbens and prefrontal cortex) which promotes the sensation of pleasure. Also, THC alters the functioning of the visual and auditory cortex of the brain, which are responsible for processing sensory information. As a result, under the influence of marijuana, the perception of time, sound and color is altered.

Why doesn’t CBD get high?

On the other hand, CBD has a different effect on the endocannabinoid system of the brain, which determines that its effect when consumed is different from that of THC. CBD interacts with CB1 and CB2 receptors in such a way that it antagonizes the effects of substances that activate or bind to them, such as THC (8).

Thus, CBD does not produce the “high” of THC, but acts in the brain through other pathways (activating TRPV1 vanilloid receptors and 5-HT1A serotonin receptors) to regulate pain, reduce anxiety, modulate mood and promote sleep (1-7).

For example, think of the endocannabinoid receptors as a lock, and their agonists (substances that bind) as the key. THC, being an agonist, fully enters the receptor lock and opens the door (or activates certain mechanisms), but CBD is like that alternate lock that some locks have. That is, CBD binds through a different site than THC (allosteric site), which is not the cleft through which the key enters. So, as the CBD is interacting with the lock when the key (the THC) is inserted, it antagonizes its effect, or alters the lock so that it does not turn and open the door.

Numerous studies have shown that CBD does not alter perception or induce intoxication states, and no significant psychoactive effects associated with CBD consumption have been reported. Therefore, it is safe to say that CBD does not get you high.

The different effects of THC and CBD are the result of the different spatial distribution of the atoms that make up the two cannabinoid molecules. While the CBD atoms are arranged in a linear structure, the THC atoms form a terminal cyclic ring at one end.

Other myths and facts about CBD

CBD is not psychoactive

Well, CBD doesn’t get you high, but CBD is actually psychoactive (although it doesn’t have the same psychoactive effects as THC in marijuana). By definition, a psychoactive substance is any substance with the potential to affect the mental state.

Although the term psychoactive can evoke a number of connotations associated with drugs or illegality, not all psychoactives are illegal drugs. Psychoactive substances are substances as common and varied as caffeine, nicotine, psychedelics, alcohol, central nervous system drugs , among many others.

If you analyze the above list, you will realize that CBD is actually a psychoactive substance, as it has the ability to act on the brain by interacting with the central nervous system.

However, to avoid falling into controversy and to further highlight the difference between CBD and its better known sibling (THC), CBD is usually considered to be non-psychoactive, or CBD is said to not have the same psychoactive effects as THC.

CBD is not psychotropic.

True: CBD is not psychotropic. Although sometimes the terms “psychotropic” and “psychoactive” are used synonymously, by etymological root or the fundamental root of the word, “psychotropic” from Greek psykhe‘soul’, and tropes(9), is a chemical agent that acts on the brain and generates temporary changes either of the brain or of the brain. perception, behavior or state of consciousness.

The term“psychotropic” is generally used in a medical context to refer to medications or drugs prescribed to restore mental health (10), as they have an impact on the mind, emotions or mental processes. Examples of psychotropic drugs are antidepressants, antipsychotics, anxiolytics and mood stabilizers. The effects of CBD on the brain are not considered psychotropic.

Does CBD have no side effects?

In reality, CBD can have side effects if used in excessive amounts. Since no humans have been exposed to this type of dose, this has only been verified through animal experimental models. To date, liver abnormalities, diarrhea, fatigue, vomiting and drowsiness have been reported with the use of CBD, which have been attributed to its possible interaction with other drugs (11).

Anyway, now you know that CBD is psychoactive but not stoned. I hope this article has cleared up some of your doubts and helped you to learn more about this interesting world of cannabinoids! Consult a health professional if you have any doubts about the use of CBD and its possible effects on the body.


1. de Mello Schier, A. R., de Oliveira Ribeiro, N. P., Coutinho, D. S., Machado, S., Arias-Carrion, O., Crippa, J. A., Zuardi, A. W., Nardi, A. E., & Silva, A. C. (2014). Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa. CNS & neurological disorders drug targets, 13(6), 953-960.

2. Crippa, J. A., Derenusson, G. N., Ferrari, T. B., Wichert-Ana, L., Duran, F. L., Martin-Santos, R., Simões, M. V., Bhattacharyya, S., Fusar-Poli, P., Atakan, Z., Santos Filho, A., Freitas-Ferrari, M. C., McGuire, P. K., Zuardi, A. W., Busatto, G. F., & Hallak, J. E. (2011). Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. Journal of psychopharmacology (Oxford, England), 25(1), 121-130.

3. Bergamaschi, M. M. M., Queiroz, R. H., Chagas, M. H., de Oliveira, D. C., De Martinis, B. S., Kapczinski, F., Quevedo, J., Roesler, R., Schröder, N., Nardi, A. E., Martín-Santos, R., Hallak, J. E., Zuardi, A. W., & Crippa, J. A. (2011). Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 36(6), 1219-1226.

4. Shannon, S., Lewis, N., Lee, H., & Hughes, S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. The Permanente journal, 23, 18-041.

5. Genovese, T., Cordaro, M., Siracusa, R., Impellizzeri, D., Caudullo, S., Raffone, E., Macrí, F., Interdonato, L., Gugliandolo, E., Interlandi, C., Crupi, R., D’Amico, R., Fusco, R., Cuzzocrea, S., & Di Paola, R. (2022). Molecular and Biochemical Mechanism of Cannabidiol in the Management of the Inflammatory and Oxidative Processes Associated with Endometriosis. International journal of molecular sciences, 23(10), 5427.

6. Urits, I., Gress, K., Charipova, K., Habib, K., Lee, D., Lee, C., Jung, J. W., Kassem, H., Cornett, E., Paladini, A., Varrassi, G., Kaye, A. D., & Viswanath, O. (2020). Use of cannabidiol (CBD) for the treatment of chronic pain. Best practice & research. Clinical anaesthesiology, 34(3), 463-477.

7. Liang, A. L., Gingher, E. L., & Coleman, J. S. (2022). Medical Cannabis for Gynecologic Pain Conditions: A Systematic Review. Obstetrics and gynecology, 139(2), 287-296.

8. Peres, F. F. F., Lima, A. C., Hallak, J. E. C., Crippa, J. A., Silva, R. H., & Abílio, V. C. (2018). Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?. Frontiers in pharmacology, 9, 482.

9. Etymologies of Chile (2021). Dictionary explaining the origin of words. Accessed May 20, 2023. Available at:

10. Cooper, J. W., Freeman, M. H., Cook, C. L., & Burfield, A. H. (2007). Assessment of psychotropic and psychoactive drug loads and falls in nursing facility residents. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 22(6), 483-489.

11. Huestis, M. A., Solimini, R., Pichini, S., Pacifici, R., Carlier, J., & Busardò, F. P. (2019). Cannabidiol Adverse Effects and Toxicity. Current neuropharmacology, 17(10), 974-989.

12. Campos, A. C., Fogaça, M. V., Sonego, A. B., & Guimarães, F. S. (2016). Cannabidiol, neuroprotection and neuropsychiatric disorders. Pharmacological research, 112, 119-127.

Masha Burelo
Investigadora en cannabinoides | Doctoranda en Neurociencia

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