CBD as an anti-inflammatory: Properties and uses - Cannactiva

CBD as an anti-inflammatory: Properties and how to use it

Climber using anti-inflammatory CBD

In recent years, the cannabidiol (CBD) a non-psychoactive compound present in the cannabis plant, has been the subject of numerous studies for its anti-inflammatory properties, and its potential benefit in the treatment of certain conditions.

In this article, we explore the underlying mechanisms that make CBD act as an anti-inflammatory, as well as the most recent clinical evidence and scientific findings. In addition, we resolve the main concerns and limitations surrounding the use of CBD as an anti-inflammatory therapy and future research prospects.

Introduction to CBD and inflammation

What is CBD and what are its properties?

Cannabidiol, more commonly known as CBD, is a compound of the Cannabis sativa plant that does not alter the state of consciousness and to which various positive properties for well-being and health have been attributed.

Within the pharmacological profile of CBD is its anti-inflammatory power. Since this is one of its most relevant properties, we will explain a little more about the anti-inflammatory power of CBD below.

What is inflammation?

Inflammation is a natural response of the body that occurs as a result of injury, irritation or infection. The purpose of inflammation is to restore tissue integrity or health. In other words, the body’s own immune system produces pro-inflammatory substances, which serve to attract other immune cells to the site that needs to be repaired in order to return to a normal state of health.

Therefore, inflammation, understood as an acute or punctual reaction, is beneficial and necessary for recovery to occur. But sometimes this inflammatory immune response becomes chronic, and can be harmful (1). When inflammation begins to harm the body, the use of anti-inflammatory drugs is recommended. These drugs are responsible for reversing or decreasing the inflammatory process.

Anti-inflammatory properties of CBD

Why is CBD anti-inflammatory?

CBD is anti-inflammatory as it is able to reduce or inhibit inflammation through its interaction with the endocannabinoid system. endocannabinoid system and other signaling pathways. The endocannabinoid system is a key regulatory system that helps maintain balance or homeostasis in the body, including the regulation of pain and inflammation.

Through its interaction with the endocannabinoid system, CBD can activate or inhibit the mechanisms that modulate the body’s inflammatory response after an injury occurs or when a disease is present.

How does CBD work to reduce inflammation?

CBD interacts with the cannabinoid receptors CB1 and CB2 of the endocannabinoid system, which are present throughout the body, including in the immune system. When CBD binds to these receptors, it can help reduce inflammation by inhibiting the release of pro-inflammatory substances.

CBD is a phytocannabinoid that can interact with the endocannabinoid system through its inverse agonism with CB1 and CB2 receptors. It also has the capacity to activate other receptors in our body, including TRPV1 vanilloid receptors and peroxisome proliferator-activated receptors gamma (PPAR gamma), which are involved in inflammation and oxidation (2).

Mechanism of action of CBD as an anti-inflammatory agent

Once CBD interacts with these receptors or drug targets, it activates or modulates machinery that will help alleviate inflammation. Some of the mechanisms responsible for CBD’s anti-inflammatory properties are:

  • CBD inhibits the production of compounds that are mediators of inflammation such as cytokines and chemokines (3). These are proinflammatory proteins responsible for attracting immune system cells to the site where inflammation should be generated.
  • CBD reduces the activation of immune cells that contribute to inflammation, e.g. T cells (4) and macrophages (5).
  • It also inhibits the enzymes cyclooxygenase (COX; 6) and lipooxygenase (LOX;7). They are involved in the production of prostaglandins and leukotrienes, which are inflammatory mediators.

Potential uses of CBD as an anti-inflammatory agent

How does CBD help to reduce inflammation?

To put this in context, the drugs or therapeutic compounds that we take to relieve pain or inflammation travel through the bloodstream until they find the site where they will have an effect, this is because their targets of action are located at these sites.

CBD, having as its target the different receptors that modulate inflammation, when traveling through the bloodstream will reach the site where this inflammatory process is occurring and therefore the targets where it can act.

Potential therapeutic use of CBD as an anti-inflammatory agent

Scientific research has described the use of CBD as a joint anti-inflammatory, which together with CBD’s ability to modulate the immune response (8) may benefit patients with rheumatoid arthritis (9) and osteoarthritis (10).

In addition, it can help provide relief from skin inflammation, making CBD a very good treatment for psoriasis. psoriasis acne and eczema (11).

On the other hand, CBD as an anti-inflammatory can have an effect on the lungs and digestive system (12), making it a potential therapeutic for asthma (13) and inflammatory bowel disease (12).

What are the benefits of CBD for inflammation?

In addition to CBD’s anti-inflammatory capacity, CBD is also characterized by its analgesic properties by having effects on the receptors involved in nociception or pain perception (14).

Likewise, CBD has antioxidant properties and the ability to reduce oxidative stress. CBD can reduce the production of free radicals or interfere with their damaging action (15, 16). This antioxidant capacity of CBD promotes the health of our body’s cells and indirectly reduces inflammation.

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How to use cannabidiol for inflammation

Studies have shown that CBD can act as an anti-inflammatory when applied topically, for example in CBD pain creams where there may be efficacy of CBD as an anti-inflammatory and local analgesic.

What is the best way to take CBD for inflammation?

A massage with the best anti-inflammatory CBD cream can help you relieve pain and inflammation over the area affected by pain. We recommend using high quality physiotherapy CBD products made with Full Spectrum CBD oil to ensure that the CBD has adequate potency.

The use of CBD for inflammation has also been demonstrated orally, through capsules or CBD capsules or drops . However, please note that the oral use of cannabidiol is not regulated in some countries.

The use of CBD for airway inflammation has also been demonstrated, such as the use of CBD Vape Pen y vaporizations .

On the other hand, you should know that CBD is not an anti-inflammatory drug as we know it. Although there are clinical studies demonstrating its anti-inflammatory effects, its use for all these conditions is not approved, at least for the time being.

If you have a significant bruise or inflammation and are looking for an anti-inflammatory drug, it is best to consult with your physician about the prescription options available.

What dose of CBD is used for inflammation?

The effective dose of CBD as an anti-inflammatory does not exist as such. We recommend that you consult your physician for information on the most appropriate treatment for the specific condition requiring anti-inflammatory action, as well as complementary therapies of proven anti-inflammatory efficacy, such as diet, exercise or rest.

How often should I take CBD for inflammation?

Broadly speaking, CBD is used in low doses and gradually increased according to individual tolerance and desired effects. Keep in mind that the optimal dose for each individual is highly variable.

Are there any drug interactions I should be aware of when taking CBD for inflammation?

Inflammation occurs as a secondary effect to tissue damage or primary disease. Therefore, there is the potential for CBD to have drug-drug interactions with the drugs being administered to treat the primary condition.

To learn more about this topic, check out our post on. CBD and drug interactions . There you can find out how the medications you are using might be affected if you use CBD.

We remind you that this is an informative article that is not intended to prevent, diagnose or treat any disease. Its content can complement, but never replace, the diagnosis or treatment of any disease or symptom. Cannactiva products are not medicines. Consult your doctor before using CBD.

Referencias
  1. Medzhitov R. (2008). Origin and physiological roles of inflammation. Nature, 454(7203), 428-435. https://doi.org/10.1038/nature07201
  2. Peres, F. F. F., Lima, A. C., Hallak, J. E. C., Crippa, J. A., Silva, R. H., & Abílio, V. C. (2018). Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?. Frontiers in pharmacology, 9, 482. https://doi.org/10.3389/fphar.2018.00482.
  3. Sermet, S., Li, J., Bach, A., Crawford, R. B., & Kaminski, N. E. (2021). Cannabidiol selectively modulates interleukin (IL)-1β and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology, 464, 153016. https://doi.org/10.1016/j.tox.2021.153016
  4. Kozela, E., Lev, N., Kaushansky, N., Eilam, R., Rimmerman, N., Levy, R., Ben-Nun, A., Juknat, A., & Vogel, Z. (2011). Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice. British journal of pharmacology, 163(7), 1507-1519. https://doi.org/10.1111/j.1476-5381.2011.01379.x
  5. Yekhtin, Z., Khuja, I., Meiri, D., Or, R., & Almogi-Hazan, O. (2022). Differential Effects of D9 Tetrahydrocannabinol (THC)- and Cannabidiol (CBD)-Based Cannabinoid Treatments on Macrophage Immune Function In Vitro and on Gastrointestinal Inflammation in a Murine Model. Biomedicines, 10(8), 1793. https://doi.org/10.3390/biomedicines10081793
  6. Cosentino, M., Legnaro, M., Luini, A., Ferrari, M., Sodergren, M., Pacchetti, B., & Marino, F. (2022). Effect of Cannabidiol on Cyclooxygenase Type 1 and 2 Expression and Function in Human Neutrophils. Cannabis and cannabinoid research, 10.1089/can.2022.0008. Advance online publication. https://doi.org/10.1089/can.2022.0008
  7. Massi, P., Valenti, M., Vaccani, A., Gasperi, V., Perletti, G., Marras, E., Fezza, F., Maccarrone, M., & Parolaro, D. (2008). 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. Journal of neurochemistry, 104(4), 1091-1100. https://doi.org/10.1111/j.1471-4159.2007.05073.x
  8. Aziz, A. I., Nguyen, L. C., Oumeslakht, L., Bensussan, A., & Ben Mkaddem, S. (2023). Cannabinoids as Immune System Modulators: Cannabidiol Potential Therapeutic Approaches and Limitations. Cannabis and cannabinoid research, 8(2), 254-269. https://doi.org/10.1089/can.2022.0133
  9. Lowin, T., Tingting, R., Zurmahr, J., Classen, T., Schneider, M., & Pongratz, G. (2020). Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts. Cell death & disease, 11(8), 714. https://doi.org/10.1038/s41419-020-02892-1
  10. Vela, J., Dreyer, L., Petersen, K. K., Arendt-Nielsen, L., Duch, K. S., & Kristensen, S. (2022). Cannabidiol treatment in hand osteoarthritis and psoriatic arthritis: a randomized, double-blind, placebo-controlled trial. Pain, 163(6), 1206-1214. https://doi.org/10.1097/j.pain.0000000000002466
  11. Sivesind, T. E., Maghfour, J., Rietcheck, H., Kamel, K., Malik, A. S., & Dellavalle, R. P. (2022). Cannabinoids for the Treatment of Dermatologic Conditions. JID innovations : skin science from molecules to population health, 2(2), 100095. https://doi.org/10.1016/j.xjidi.2022.100095
  12. Martínez, V., Iriondo De-Hond, A., Borrelli, F., Capasso, R., Del Castillo, M. D., & Abalo, R. (2020). Cannabidiol and Other Non-Psychoactive Cannabinoids for Prevention and Treatment of Gastrointestinal Disorders: Useful Nutraceuticals?. International journal of molecular sciences, 21(9), 3067. https://doi.org/10.3390/ijms21093067. https://doi.org/10.3390/ijms21093067
  13. Vuolo, F., Abreu, S. C., Michels, M., Xisto, D. G., Blanco, N. G., Hallak, J. E., Zuardi, A. W., Crippa, J. A., Reis, C., Bahl, M., Pizzichinni, E., Maurici, R., Pizzichinni, M. M. M. M., Rocco, P. R. M., & Dal-Pizzol, F. (2019). Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma. European journal of pharmacology, 843, 251-259. https://doi.org/10.1016/j.ejphar.2018.11.029
  14. Mlost, J., Bryk, M., & Starowicz, K. (2020). Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action. International journal of molecular sciences, 21(22), 8870. https://doi.org/10.3390/ijms21228870
  15. Atalay, S., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2019). Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants (Basel, Switzerland), 9(1), 21. https://doi.org/10.3390/antiox9010021
  16. Ben-Shabat, S., Hanus, L. O., Katzavian, G., & Gallily, R. (2006). New cannabidiol derivatives: synthesis, binding to cannabinoid receptor, and evaluation of their anti-inflammatory activity. Journal of medicinal chemistry, 49(3), 1113-1117. https://doi.org/10.1021/jm050709m

Masha Burelo
Investigadora en cannabinoides | Doctoranda en Neurociencia

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