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Benefits of CBD for acne

CBD cream and oil for acne-prone skin

If you are looking for effective acne treatment products, buying CBD online is the ultimate natural solution. In this post, we explain why CBD is a promising alternative to conventional creams to treat acne effectively and safely.

What is acne and what is its treatment?

Acne is a common skin condition characterized by the presence of blackheads, whiteheads, pimples and even more severe forms such as cysts and nodules.

This skin condition is caused by different factors, such as overproduction of sebum, irregular shedding of skin cells, and accumulation of Cutibacterium acnes bacteria in the skin.

It can affect people of all ages, and the most important factor in the development of acne is the excessive production of sebum, an oily substance intended to protect the skin. Excess sebum causes clogging of the hair follicles, creating a suitable environment for bacterial proliferation. This results in inflammation and formation of acne lesions.

Conventional acne treatment includes topical applications such as retinoids and benzoyl peroxide, as well as oral medications such as isotretinoin and even the prescription of oral contraceptives in women. Although there are several treatments available on the market, some of them may have unwanted side effects.

What is CBD and how does it work for acne?

The CBD or cannabidiol is one of the main non-psychoactive compounds present in the cannabis plant(Cannabis sativa). Unlike THC (tetrahydrocannabinol), another well-known compound in cannabis, CBD does not induce a “high”.

Although CBD comes from the cannabis plant, it has therapeutic applications and is not associated with psychoactive effects.

CBD interacts with the endocannabinoid system present in the skin (1, 2, 3) and other organs, thus affecting various physiological processes. More specifically, below we are going to focus on the beneficial effects of CBD for acne.

Benefits of CBD for acne

It has been found that topical application of CBD oil and CBD cream can be an effective treatment for acne by influencing its healing through multiple mechanisms:

CBD has anti-inflammatory properties, regulates sebum production, has antibacterial potential, can influence skin cell proliferation and offers additional benefits for various skin conditions. Preliminary research suggests its potential in the treatment of acne.

Anti-inflammatory action

CBD has anti-inflammatory properties that can reduce redness and swelling commonly associated with acne lesions (4). These anti-inflammatory properties of cannabidiol are also used in many other conditions.

Reduced sebum production

Excessive sebum production is the main cause of acne. CBD regulates sebum production by interacting with the cells that make up the sebaceous glands, which helps prevent clogged pores.

The skin’s sebum production is regulated by the endocannabinoid system, on which CBD acts.

Scientific studies mention that sebaceous cells (the cells that produce sebum) found in the skin use endocannabinoid signaling to significantly regulate and suppress the production of lipids or fats such as sebum (1), so CBD may have a beneficial effect on acne.

Cannactiva CBD Cosmetic Facial Cream
Cannactiva CBD Cosmetic Facial Cream

Antibacterial properties

It has been suggested that CBD has antibacterial properties (5). Although CBD has not been shown to inhibit the growth of Cutibacterium acnes bacteria alone, it has been documented in clinical studies that CBD can potentiate the antibacterial effect of Centella asiatica for the treatment of acne (6).

Effect on the proliferation of skin cells.

CBD, by interacting with the endocannabinoid system, could influence cell growth and differentiation. This interaction is essential in the healing and renewal processes of the skin and can be a treatment pathway to combat acne.

Cell growth is a complex process that is influenced by signaling from the endocannabinoid system (7). And it is possible that CBD has an impact on skin cell growth and differentiation, which, although limited (8, 9), could contribute to the healing and renewal processes essential for controlling acne.

Additional Benefits

In addition to its effects on acne, CBD oil and CBD cream may offer other skin benefits, such as relief from psoriasis, eczema, and atopic dermatitis (10).

In addition, CBD-infused products often include a variety of other ingredients that can offer cosmetic benefits such as skin hydration and improved skin texture.

How to use CBD for acne

Studies with CBD oils and creams to treat acne are small. However, there is one study that used a product with 3% cannabis seed extract to successfully decrease sebum production (12), therefore, oils or creams enriched with 0.1-10% CBD may represent a benefit to restore skin health.


Apply a small amount topically, directly to the affected areas after cleansing the skin. Generally, a few drops of 2.5% CBD oil are sufficient, although it is not yet ruled out that other concentrations of CBD oil may be effective as well.

It is important to apply the CBD oil several times a day, since the most important thing is that the desired area always has CBD available to act.

CBD Cream

Gently massage the CBD cream on the affected areas. The dosage varies according to the product, the general instruction being an application two to three times a day. Consult the product instructions or a professional for specific recommendations.

Considerations and precautions

It is essential to remember that the efficacy of CBD varies from person to person. Patience and consistency are key to obtain the best results.

Before starting any new skin care regimen, even one involving CBD oil or CBD cream, consult a practitioner, especially if there is a pre-existing condition or other medications are being taken, including ointments, retinoids and other topical acne products.

Side effects

CBD is generally considered safe, but some people may experience side effects such as dizziness, diarrhea and changes in appetite. If any adverse effects are experienced, discontinue use and consult a physician.

In conclusion…

CBD, with its multiple mechanisms of action, offers a promising approach to the treatment of acne. However, more research is needed to establish a long-term safety profile for CBD products in the treatment of acne.

Numerous studies have explored the potential of CBD as a treatment for acne. While research is still ongoing, preliminary findings indicate that the anti-inflammatory and sebum-regulating properties of CBD make it a promising candidate for the treatment of acne (11).

Note: This is an informational article that is not intended to prevent, diagnose or treat any disease or symptom. Its content can complement, but never replace, the diagnosis or treatment of any disease or symptom. Cannactiva products are not medicines and are intended for external use. Consult your physician for more information and personalized acne treatment advice before using CBD.

  1. Dobrosi, N., Tóth, B. I., Nagy, G., Dózsa, A., Géczy, T., Nagy, L., Zouboulis, C. C., Paus, R., Kovács, L., & Bíró, T. (2008). Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 22(10), 3685-3695.
  2. Karsak, M., Gaffal, E., Date, R., Wang-Eckhardt, L., Rehnelt, J., Petrosino, S., Starowicz, K., Steuder, R., Schlicker, E., Cravatt, B., Mechoulam, R., Buettner, R., Werner, S., Di Marzo, V., Tüting, T., & Zimmer, A. (2007). Attenuation of allergic contact dermatitis through the endocannabinoid system. Science (New York, N.Y.), 316(5830), 1494-1497.
  3. Ständer, S., Schmelz, M., Metze, D., Luger, T., & Rukwied, R. (2005). Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin. Journal of dermatological science, 38(3), 177-188.
  4. Peyravian, N., Deo, S., Daunert, S., & Jimenez, J. J. (2022). The Anti-Inflammatory Effects of Cannabidiol (CBD) on Acne. Journal of inflammation research, 15, 2795-2801.
  5. Blaskovich, M. A. T., Kavanagh, A. M., Elliott, A. G., Zhang, B., Ramu, S., Amado, M., Lowe, G. J., Hinton, A. O., Pham, D. M. T., Zuegg, J., Beare, N., Quach, D., Sharp, M. D., Pogliano, J., Rogers, A. P., Lyras, D., Tan, L., West, N. P., Crawford, D. W., Peterson, M. L. Thurn, M. (2021). The antimicrobial potential of cannabidiol. Communications biology, 4(1), 7.
  6. Cohen, G., Jakus, J., Baroud, S., Gvirtz, R., & Rozenblat, S. (2023). Development of an Effective Acne Treatment Based on CBD and Herbal Extracts: Preliminary In Vitro, Ex Vivo, and Clinical Evaluation. Evidence-based complementary and alternative medicine : eCAM, 2023, 4474255.
  7. Baswan, S. M., Klosner, A. E., Glynn, K., Rajgopal, A., Malik, K., Yim, S., & Stern, N. (2020). Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders. Clinical, cosmetic and investigational dermatology, 13, 927-942.
  8. Chelliah, M. P., Zinn, Z., Khuu, P., & Teng, J. M. C. (2018). Self-initiated use of topical cannabidiol oil for epidermolysis bullosa. Pediatric dermatology, 35(4), e224-e227.
  9. Sangiovanni, E., Fumagalli, M., Pacchetti, B., Piazza, S., Magnavacca, A., Khalilpour, S., Melzi, G., Martinelli, G., & Dell’Agli, M. (2019). Cannabis sativa L. extract and cannabidiol inhibit in vitro mediators of skin inflammation and wound injury. Phytotherapy research : PTR, 33(8), 2083-2093.
  10. Petrosino, S., Verde, R., Vaia, M., Allarà, M., Iuvone, T., & Di Marzo, V. (2018). Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis. The Journal of pharmacology and experimental therapeutics, 365(3), 652-663.
  11. Oláh, A., Tóth, B. I., Borbíró, I., Sugawara, K., Szöllõsi, A. G., Czifra, G., Pál, B., Ambrus, L., Kloepper, J., Camera, E., Ludovici, M., Picardo, M., Voets, T., Zouboulis, C. C., Paus, R., & Bíró, T. (2014). Cannabidiol exerts sebostatic and anti-inflammatory effects on human sebocytes. The Journal of clinical investigation, 124(9), 3713-3724.
  12. Ali, A., & Akhtar, N. (2015). The safety and efficacy of 3% Cannabis seeds extract cream for reduction of human cheek skin sebum and erythema content. Pakistan journal of pharmaceutical sciences, 28(4), 1389-1395.

Masha Burelo
Investigadora en cannabinoides | Doctoranda en Neurociencia

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